Indications
Anhydrous benzoyl peroxide is a skin medicine used to treat mild to moderate acne, including blackheads, whiteheads and red, inflamed spots. It is often combined with the antibiotic Clindamycin in a gel, which works better than either medicine alone and helps prevent bacteria becoming resistant to the antibiotic.
How It Works
When applied to the skin, benzoyl peroxide releases oxygen that kills the acne-causing bacteria (Cutibacterium acnes) living in blocked pores. It also gently peels the top layer of skin and helps unblock pores, so fewer new spots form. Bacteria do not become resistant to benzoyl peroxide.
Dosage and Administration
Use as directed by your doctor or as on the label. Gels containing it are usually applied once a day, in the evening. Wash the face gently with a mild cleanser, pat it dry, then spread a thin layer over the whole affected area, not just on single spots. Avoid the eyes, lips, inside the nose and broken skin. Wash your hands after use. Results usually start to show after 2 to 4 weeks, and full benefit may take longer.
Interactions
- Using it at the same time as other drying or peeling products (such as Salicylic acid, Sulphur, alcohol-based toners or abrasive scrubs) can increase irritation.
- Applying it together with Tretinoin can reduce the effect of Tretinoin; if both are prescribed, use them at different times of day unless told otherwise.
- Topical Erythromycin should not be used at the same time as Clindamycin-containing gels.
Contraindications
- Allergy to benzoyl peroxide or any ingredient.
- For combination gels with Clindamycin: allergy to Clindamycin or Lincomycin, or a history of inflammatory bowel disease or antibiotic-related colitis.
Side Effects
Common effects are dryness, peeling, redness, stinging or a burning feeling, especially in the first weeks. These usually settle as the skin gets used to it. It can bleach hair, clothes, towels and bed linen.
Get urgent medical help if you have severe burning, swelling, blistering, swelling of the face, eyes or lips, hives or difficulty breathing. With Clindamycin combinations, see a doctor straight away if you develop severe or bloody diarrhoea or stomach cramps.
Pregnancy and Lactation
Very little benzoyl peroxide is absorbed through the skin, and it is generally considered acceptable in pregnancy and breastfeeding when used as directed. Ask your doctor first, especially for combination products. If breastfeeding, do not apply it to the breast area.
Precautions and Warnings
- Avoid strong sunlight and sunlamps; use a sunscreen during the day.
- Start with a small area if your skin is sensitive.
- Keep away from hair and coloured fabrics, as it bleaches them.
- Do not use on sunburned, broken or eczema-affected skin.
Overdose
Using too much does not clear acne faster and may cause severe redness and peeling. If this happens, stop for a few days and then restart less often. If swallowed, contact a doctor for advice.
Therapeutic Class
Topical anti-acne agent, antibacterial and keratolytic (skin-peeling) agent.
Storage
Store below 30°C in a dry place, away from light and out of the reach of children. Some combination gels need to be kept in the fridge before or after dispensing; follow the pack instructions.
Prepared by the Oshud Alo team from standard drug references. For information only; always follow your doctor's advice.