Indications
Dextran 70 is a large sugar molecule used in two very different forms. In eye drops, usually combined with Hypromellose, it is an artificial tear used to relieve dry, gritty, burning or tired eyes caused by dry eye disease, screen use, wind, air conditioning or contact lenses. As an intravenous solution in hospital, it is a plasma volume expander used to restore blood volume in shock caused by bleeding, burns or surgery.
How It Works
In eye drops, Dextran 70 holds water and forms a smooth, moist film over the surface of the eye, much like natural tears, which lubricates and protects the eye. When given into a vein, its large molecules stay inside the blood vessels and draw fluid into the bloodstream, which increases blood volume and supports blood pressure.
Dosage and Administration
Eye drops: usually 1 to 2 drops in the affected eye(s) as needed, often 3 to 4 times a day or more, or as directed on the label. Do not touch the dropper tip to the eye or any surface. Remove soft contact lenses before use unless the product is labelled as suitable for lenses. Intravenous solution: given only by a doctor or nurse as an infusion in hospital, with the amount set by the doctor.
Interactions
- Eye drops: if you use other eye medicines, wait at least 5 minutes between them and use the lubricant last.
- Intravenous Dextran can interfere with some blood tests, including blood grouping and cross matching, so blood samples are taken before infusion where possible. It may increase the effect of blood thinners.
Contraindications
- Allergy to Dextran or any ingredient of the product.
- For the intravenous form: severe heart failure, severe bleeding disorders, very low platelets, severe kidney failure with little urine, and severe fluid overload.
Side Effects
Eye drops may cause brief blurred vision, mild stinging or a sticky feeling on the eyelids. Intravenous infusion may rarely cause allergic reactions, fluid overload, bleeding problems or kidney problems; these are watched for by the medical team.
Get urgent medical help if you have eye pain, changes in vision, continued redness or irritation that gets worse, or if during an infusion there is swelling of the face, rash, wheezing, trouble breathing or feeling faint.
Pregnancy and Lactation
Lubricant eye drops are generally considered safe in pregnancy and breastfeeding, as very little is absorbed. Intravenous Dextran is used in pregnancy only when the doctor decides it is necessary.
Precautions and Warnings
- Blurred vision after the drops may last a short time; wait until it clears before driving.
- See a doctor if eye symptoms persist for more than 3 days.
- Discard the bottle within the time stated on the label after opening (often 28 days).
Overdose
Extra eye drops are not harmful; rinse with clean water if there is discomfort. Overdose of the intravenous form can cause fluid overload and bleeding, which is managed in hospital.
Therapeutic Class
Ocular lubricant (artificial tear); plasma volume expander.
Storage
Store below 30°C in a dry place, away from light and out of the reach of children. Do not freeze. Close the bottle tightly after use. Infusion bags are stored as directed on the pack.
Prepared by the Oshud Alo team from standard drug references. For information only; always follow your doctor's advice.