Indications
Panthenol (also called Dexpanthenol or provitamin B5) is a form of vitamin B5 (pantothenic acid). On the skin it is used in creams, ointments and lotions to soothe and help heal minor wounds, scrapes, mild burns and sunburn, nappy rash, sore or cracked nipples during breastfeeding, and dry, rough or irritated skin. It is also included in multivitamin products, eye and nasal products, and hair care. In some hospitals it has been given by injection for bowel slowdown after surgery.
How It Works
Panthenol is absorbed into the skin and converted into pantothenic acid, which is part of coenzyme A, a substance cells need to make fats and energy. This supports the repair of the skin barrier and the growth of new skin cells. Panthenol also attracts and holds water, which moisturises the skin and reduces itching and redness.
Dosage and Administration
Skin products: apply a thin layer to the clean affected area once or several times a day as needed, or as directed on the label. For nipples, apply after each feed. For nappy rash, apply at each nappy change. Oral multivitamins: take as directed on the label. Injection: given only by a doctor or nurse.
Interactions
Skin products have no known important interactions. The injection should not be given within 12 hours of Neostigmine or similar medicines, and is avoided with Succinylcholine because it may prolong muscle relaxation.
Contraindications
- Allergy to Panthenol, Dexpanthenol or any ingredient of the product.
- Injection: haemophilia or bowel blockage caused by a physical obstruction.
Side Effects
Skin products are very well tolerated. Rarely, itching, redness, rash or contact allergy may occur. Injection may rarely cause allergic reactions, stomach cramps or diarrhoea.
Get urgent medical help if you notice swelling of the face, lips or throat, difficulty breathing, or a widespread itchy rash, or if a wound shows signs of infection such as pus, spreading redness, fever or increasing pain.
Pregnancy and Lactation
Skin products are considered safe in pregnancy and breastfeeding. When used on the nipples, it does not need to be wiped off before feeding unless the label says so. Oral supplements are safe at normal daily amounts.
Precautions and Warnings
Do not use on deep, heavily bleeding or infected wounds, or serious burns, without medical advice. Avoid contact with the eyes unless it is an eye product. See a doctor if a wound or skin problem does not improve within about 1 week.
Overdose
Panthenol has very low toxicity. Swallowing a small amount of cream is not expected to cause harm, though it may cause mild stomach upset. Seek advice if a large amount is swallowed.
Therapeutic Class
Vitamin B5 derivative (skin protectant and emollient; vitamin supplement).
Storage
Store below 30°C in a dry place, away from light and out of the reach of children. Close the tube or container tightly after use.
Prepared by the Oshud Alo team from standard drug references. For information only; always follow your doctor's advice.