Indications
Spiramycin is a macrolide antibiotic. It is used for infections of the throat, sinuses, chest, skin and mouth (including dental infections) caused by sensitive bacteria, especially in people allergic to penicillin. It is also used to treat toxoplasmosis during pregnancy, to lower the chance of the parasite passing to the baby.
How It Works
Spiramycin attaches to the ribosomes of bacteria, the parts of the cell that make proteins. This stops the bacteria from making the proteins they need, so they cannot grow and multiply, allowing the body’s defences to clear the infection. It reaches high levels in tissues such as the tonsils, lungs and placenta.
Dosage and Administration
The usual adult dose is 6 to 9 million IU a day, divided into 2 or 3 doses, for the number of days prescribed. Doses for children depend on body weight, and toxoplasmosis in pregnancy is treated as prescribed by the specialist. Take with water, preferably at regular times. Finish the full course even if you feel better.
Interactions
Spiramycin may lower the levels of Levodopa when taken with Carbidopa. Use with care alongside medicines that affect heart rhythm (prolong the QT interval). Tell your doctor about all medicines you take.
Contraindications
- Allergy to Spiramycin or other macrolide antibiotics.
Side Effects
Nausea, vomiting, diarrhoea, stomach pain and skin rash can occur. Rarely, liver problems, tingling of the skin, blood changes or severe skin reactions occur.
Get urgent medical help for swelling of the face or throat, difficulty breathing, a blistering or peeling rash, yellow skin or eyes, palpitations or fainting, or severe or bloody diarrhoea.
Pregnancy and Lactation
Spiramycin is considered suitable for use in pregnancy when prescribed, and is specifically used for toxoplasmosis in pregnancy. It passes into breast milk, so it is usually not recommended during breastfeeding; ask your doctor.
Precautions and Warnings
Use with care in liver disease and in people with heart rhythm problems. Long or repeated use can lead to resistant infections or thrush. Do not use it for viral infections such as colds.
Overdose
Overdose may cause stomach upset and, rarely, heart rhythm problems. Contact a doctor or hospital; an ECG may be needed.
Therapeutic Class
Macrolide antibiotic.
Storage
Store below 30°C in a dry place, away from light and out of the reach of children.
Prepared by the Oshud Alo team from standard drug references. For information only; always follow your doctor's advice.