Indications
Testosterone Propionate is a short-acting form (ester) of the male hormone testosterone. It is used to replace testosterone in men whose bodies make too little (male hypogonadism), and it is commonly one of the ingredients of mixed testosterone injections. Low testosterone may cause low sex drive, erection difficulties, tiredness, low mood, loss of muscle and weak bones. Specialists may occasionally use it for other hormone-related conditions.
How It Works
After an injection into muscle, the propionate ester is quickly broken down to release testosterone, so it starts working within a day or two but its effect fades within a few days. In mixed injections it gives the early rise in hormone level, while longer-acting esters keep the level up afterwards. Testosterone supports male sexual development and function, muscle and bone strength and red blood cell production.
Dosage and Administration
Given as an injection into a muscle by a doctor or nurse. Because it acts for a short time, when used alone it needs frequent injections; the exact dose and schedule are as prescribed by the doctor after blood tests. Do not use it without medical supervision or for sport or bodybuilding.
Interactions
- Warfarin and other oral anticoagulants: increased bleeding risk; INR needs closer checking.
- Insulin and medicines for diabetes: lower blood sugar is possible.
- Corticosteroids: higher risk of swelling from fluid retention.
- Ciclosporin: levels may change, so monitoring may be needed.
Contraindications
Do not use in prostate cancer or male breast cancer, in high blood calcium caused by cancer, during pregnancy or breastfeeding, or if allergic to any ingredient (including peanut or soya oil, if the injection contains it). Not for women or children unless a specialist decides.
Side Effects
- Pain, redness or a lump where the injection was given.
- Acne, oily skin, increased body or facial hair.
- Fluid retention, weight gain, raised blood pressure.
- Increase in red blood cells, breast tenderness or swelling, mood changes.
- Fall in sperm count and fertility while on treatment.
Get urgent medical help if you have chest pain, sudden breathlessness, a painful swollen calf, sudden weakness or numbness on one side, yellow skin or eyes, an erection that lasts more than 4 hours, or a severe allergic reaction.
Pregnancy and Lactation
Must not be used in pregnancy or breastfeeding because it can cause male changes in a female baby and may pass into milk.
Precautions and Warnings
Your doctor will check your blood count, PSA, liver tests and cholesterol from time to time. Tell your doctor about heart, liver or kidney disease, high blood pressure, epilepsy, migraine, diabetes, sleep apnoea or a history of blood clots. High-dose misuse can cause heart disease, liver damage, infertility and mental health problems. In adolescents it can stop growth early.
Overdose
An occasional extra dose rarely causes serious problems, but regular overdosing can cause thick blood, fluid retention and the side effects above. Speak to your doctor if too much has been given.
Therapeutic Class
Androgen (male sex hormone).
Storage
Store below 30°C, away from light, do not refrigerate, and keep out of the reach of children. In hospital, store as directed on the pack.
Prepared by the Oshud Alo team from standard drug references. For information only; always follow your doctor's advice.