Indications
Tocotrienol is a natural form of vitamin E, found mainly in palm oil, rice bran and annatto. It is used as a dietary supplement, often combined with Tocopherol (the more common form of vitamin E), as an antioxidant to support heart and blood vessel health, skin and hair health, and general wellbeing. Research suggests possible benefits for cholesterol levels, fatty liver and nerve health, but the evidence is still limited, and it is not a replacement for prescribed treatment.
How It Works
Like other forms of vitamin E, tocotrienols are fat-soluble antioxidants: they protect cell membranes from damage by unstable molecules called free radicals. Their slightly different structure lets them move easily through cell membranes. Laboratory studies suggest they may also reduce cholesterol production in the liver and calm inflammation.
Dosage and Administration
Take it as directed on the label, usually once or twice daily with a meal that contains some fat, which improves absorption. Do not take more than the recommended amount.
Interactions
High doses of vitamin E may increase the risk of bleeding when taken with blood thinners such as Warfarin, or with antiplatelet medicines such as Aspirin and Clopidogrel. Tell your doctor if you take these. Very high doses of Tocopherol may reduce the absorption of tocotrienols, so combined products are usually balanced by the manufacturer.
Contraindications
Do not use it if you are allergic to any ingredient. Avoid high-dose supplements if you have a bleeding disorder or vitamin K deficiency.
Side Effects
It is usually well tolerated. Some people may have mild stomach upset, nausea, loose stools or headache.
Get urgent medical help if you notice unusual bleeding or bruising, black stools, blood in urine, a sudden severe headache, or swelling of the face, lips or throat or difficulty breathing.
Pregnancy and Lactation
Vitamin E from food is important in pregnancy, but there is little information on tocotrienol supplements. Use them during pregnancy or breastfeeding only if a doctor advises.
Precautions and Warnings
Stop taking high-dose vitamin E supplements about two weeks before planned surgery, and tell your surgeon or dentist you take it. People with liver disease or those on long-term medicines should ask a doctor before use.
Overdose
Very large amounts may cause nausea, diarrhoea, tiredness and a higher risk of bleeding. Seek medical advice if a large amount has been taken or a child has swallowed it.
Therapeutic Class
Vitamin (vitamin E, antioxidant supplement).
Storage
Store below 30°C in a dry place, away from light and out of the reach of children.
Prepared by the Oshud Alo team from standard drug references. For information only; always follow your doctor's advice.