Cavitab

Indications

Vinpocetine is used in some countries to help problems linked to poor blood flow in the brain, such as:

• memory and concentration problems in older people caused by reduced blood supply to the brain;
• recovery after a stroke caused by a blocked blood vessel (not a bleed);
• dizziness and ringing in the ears linked to poor circulation.

The evidence for these uses is limited, and it should be used only on a doctor's advice.

How It Works

Vinpocetine is made from vincamine, a substance found in the lesser periwinkle plant. It is thought to widen small blood vessels in the brain, improve blood flow and help brain cells use oxygen and glucose.

Dosage and Administration

Tablets, adults: usually 5 mg to 10 mg three times a day after meals. Do not take more than 30 mg in a day. Treatment is usually reviewed after a few weeks.

Injection: given as a slow drip into a vein in hospital by a doctor or nurse, as prescribed. It is never given as a quick injection.

Children: not for use.

Interactions

• Blood thinners and antiplatelet medicines (such as Warfarin, Aspirin or Clopidogrel): possible higher risk of bleeding.
• Blood pressure medicines: blood pressure may fall further.
• Medicines that affect heart rhythm: extra care is needed.

Tell your doctor about all medicines and supplements you take.

Contraindications

• Pregnancy and breastfeeding
• The early phase of a stroke caused by bleeding in the brain
• Severe heart disease or serious heart rhythm problems
• Children
• Allergy to Vinpocetine

Side Effects

Possible: headache, dizziness, flushing, trouble sleeping, stomach upset, heartburn, dry mouth, low blood pressure and a fast heartbeat.

Get medical help at once for chest pain, an irregular heartbeat, fainting, unusual bleeding or bruising, sudden weakness or numbness on one side of the body, trouble speaking, or swelling of the face and trouble breathing.

Pregnancy and Lactation

Vinpocetine must not be used in pregnancy; studies suggest it may harm the unborn baby and cause miscarriage. Women who could become pregnant should not use it without a doctor's advice. It passes into breast milk and should not be used while breastfeeding.

Precautions and Warnings

• Take care if you have low blood pressure, heart rhythm problems or a bleeding disorder.
• Tell your doctor or dentist that you take it before any surgery.
• It is not a substitute for proper treatment of stroke risk factors such as high blood pressure, diabetes or high cholesterol.

Overdose

There is little information. Too much may cause low blood pressure, a fast heartbeat and dizziness. Contact a doctor or go to hospital.

Therapeutic Class

Cerebral vasodilator (medicine to improve blood flow in the brain).

Storage

Store below 30°C in a dry place, away from light and out of the reach of children.