Yohim

Indications

Yohimbine Hydrochloride comes from the bark of an African tree. It has been used to help with erectile dysfunction (difficulty getting or keeping an erection), especially when the cause is not purely physical, and to support low sexual desire in men. Evidence for its benefit is modest, and newer medicines are usually preferred. It should be used only on a doctor's advice.

How It Works

Yohimbine blocks alpha-2 adrenergic receptors in the nervous system. This increases the release of noradrenaline, a chemical messenger, which can improve blood flow into the penis and reduce the outflow of blood, helping an erection. It also acts on the brain, which may increase arousal but can also cause anxiety and a faster heartbeat.

Dosage and Administration

Take as prescribed by your doctor. A commonly used adult dose is 5.4 mg up to three times daily by mouth. It may take 2 to 3 weeks to see an effect. Do not take more than prescribed and do not combine with other sexual enhancement products.

Interactions

• Antidepressants such as Amitriptyline, Clomipramine, MAO inhibitors and some others can raise blood pressure or cause agitation when taken with Yohimbine.
• It can weaken the effect of blood pressure medicines such as Clonidine and Methyldopa.
• Stimulants, caffeine and decongestants (such as Pseudoephedrine) can increase anxiety, heart rate and blood pressure.
• It may interfere with Naltrexone and some psychiatric medicines.

Contraindications

• Allergy to Yohimbine
• High blood pressure, heart disease, chest pain or heart rhythm problems
• Kidney or liver disease
• Anxiety disorder, panic attacks, bipolar disorder, schizophrenia or post-traumatic stress disorder
• Stomach ulcer
• Women, children and older people with medical conditions

Side Effects

• Nervousness, anxiety, irritability or trouble sleeping
• Fast heartbeat or palpitations
• Raised blood pressure
• Sweating, flushing, tremor
• Headache, dizziness
• Nausea, stomach upset, frequent urination

Get urgent medical help if you develop chest pain, a very fast or irregular heartbeat, severe headache, very high blood pressure, fainting, severe panic or confusion, fits, or an erection that lasts more than 4 hours.

Pregnancy and Lactation

Yohimbine is not for use by women. It must not be used during pregnancy or breastfeeding, as it may harm the baby.

Precautions and Warnings

• Have your blood pressure and heart checked before and during treatment.
• Avoid alcohol and large amounts of caffeine.
• Erectile problems may be a sign of diabetes, heart disease or hormone problems; see a doctor for proper assessment.
• Some unregulated "herbal" sexual products contain hidden Yohimbine or other drugs; buy only registered medicines.

Overdose

Overdose can cause severe anxiety, very high blood pressure, fast heartbeat, tremor, vomiting, confusion and, rarely, seizures or heart problems. Seek emergency medical care immediately.

Therapeutic Class

Alpha-2 adrenergic blocker, used in erectile dysfunction

Storage

Store below 30°C in a dry place, away from light and out of the reach of children.