Indications
Azadirachta indica is neem, a tree widely used in Unani, Ayurvedic and folk medicine in South Asia. Preparations made from neem leaves or bark, such as tablets, capsules or syrups, are traditionally used for skin problems like acne, boils and itching, as a so-called blood purifier, and as a supportive herb for people with high blood sugar. Scientific evidence for these uses is limited, and neem does not replace prescribed treatment for diabetes, skin infections or other illnesses.
How It Works
Neem contains many active plant substances, such as nimbin, nimbidin and azadirachtin. In laboratory and small studies, these have shown antibacterial, antifungal and anti-inflammatory effects, and some may help lower blood sugar slightly. How well these effects carry over to people taking neem by mouth is not well established.
Dosage and Administration
Take as directed on the label or by a registered Unani or Ayurvedic practitioner, usually for a limited period. Do not take more than the label amount. Never give neem by mouth, and especially neem oil, to infants or young children.
Interactions
Neem may lower blood sugar and add to the effect of diabetes medicines such as Metformin, Glibenclamide or insulin, which can cause low blood sugar. It may stimulate the immune system and so reduce the effect of medicines that suppress immunity, such as Ciclosporin, Tacrolimus or steroids. Tell your doctor or pharmacist about all medicines and herbal products you use.
Contraindications
- Pregnancy, or trying to conceive (neem has been linked to miscarriage and reduced fertility).
- Infants and young children.
- Known allergy to neem.
- People who have had an organ transplant, or who have autoimmune diseases such as lupus or rheumatoid arthritis, unless a doctor advises it.
Side Effects
When taken by mouth in label amounts for a short time, neem is usually tolerated, but it can cause nausea, vomiting, stomach upset, drowsiness and allergic skin reactions. Large amounts or long-term use may harm the liver and kidneys.
Get urgent medical help if you notice swelling of the face, lips or throat, difficulty breathing, signs of low blood sugar (shaking, sweating, confusion), yellowing of the skin or eyes, fits, or severe vomiting, especially in a child.
Pregnancy and Lactation
Do not use neem by mouth during pregnancy, as it may cause miscarriage. There is not enough safety information for breastfeeding, so avoid it unless a doctor advises it.
Precautions and Warnings
People with diabetes should check their blood sugar more often and should never stop their prescribed medicines. Stop using neem before planned surgery, as it may affect blood sugar. Neem may reduce fertility in both men and women. Skin infections that spread, or come with fever, need a doctor.
Overdose
Swallowing neem oil or large amounts of neem can be dangerous, especially for children, and may cause vomiting, drowsiness, fits, low blood sugar, liver damage and unconsciousness. Seek emergency medical help straight away.
Therapeutic Class
Unani and Ayurvedic herbal preparation.
Storage
Store below 30°C in a dry place, away from light and out of the reach of children.
Prepared by the Oshud Alo team from standard drug references. For information only; always follow your doctor's advice.