Indications
Clobetasone Butyrate is a moderately strong corticosteroid (steroid) cream or ointment used on the skin to calm inflammation and itching in conditions such as eczema, dermatitis (skin inflammation from irritants or allergy), insect bite reactions and some other inflamed skin problems that respond to steroids. Eye drop forms are used for some inflammatory eye conditions as prescribed by an eye doctor.
How It Works
Clobetasone reduces the activity of the immune cells and chemicals that cause redness, swelling and itching in the skin. It also narrows small blood vessels in the treated area, which reduces redness. It eases symptoms but does not cure the underlying condition.
Dosage and Administration
For adults and children over 12 years: apply a thin layer to the affected skin up to twice a day and rub in gently. Wash your hands afterwards unless the hands are being treated. Use for the shortest time needed; if you are using it without a prescription, see a doctor if there is no improvement within 7 days. For young children, use only as prescribed. Eye drops are used only as prescribed.
Interactions
Interactions are unlikely with normal skin use because little is absorbed. Avoid applying other skin products to the same area at the same time unless your doctor advises it. Large amounts used over wide areas for long periods may interact with medicines such as Ritonavir or Itraconazole, which can increase steroid effects.
Contraindications
Do not use on skin infected with bacteria, viruses (such as cold sores, chickenpox or shingles) or fungi unless an anti-infective is also being used, on acne, rosacea, perioral dermatitis (rash around the mouth), itching around the anus or genitals without a doctor’s advice, or if you are allergic to clobetasone.
Side Effects
Side effects are uncommon with short use. Possible effects include burning, stinging, itching or worsening of the skin where applied. Long or heavy use can cause thinning of the skin, stretch marks, visible small blood vessels, changes in skin colour and increased hair growth. Rarely, enough may be absorbed to affect the body’s own hormone production, mainly in children.
Get urgent medical help if you notice signs of a serious allergic reaction such as swelling of the face, lips or throat, or difficulty breathing. Also see a doctor if the skin becomes infected, blurred vision develops, or the condition gets clearly worse.
Pregnancy and Lactation
Use during pregnancy only on a doctor’s advice, for the shortest time and on a small area. It may be used while breastfeeding if needed, but do not apply it to the breast area just before feeding.
Precautions and Warnings
Avoid contact with the eyes. Do not use under tight dressings, bandages or nappies unless told to, as this increases absorption. Use carefully on the face and skin folds, where skin is thinner. Do not stop suddenly after long use; your doctor may reduce use gradually. Ointments and creams can make fabrics flammable when dried on clothing or bedding, so keep away from flames.
Overdose
Swallowing a small amount is unlikely to be harmful, but seek advice if a large amount is swallowed. Long-term overuse on the skin can cause steroid side effects; reduce use under medical advice.
Therapeutic Class
Topical corticosteroid (moderately potent).
Storage
Store below 30°C in a dry place, away from light and out of the reach of children. Keep the tube tightly closed.
Prepared by the Oshud Alo team from standard drug references. For information only; always follow your doctor's advice.