Indications
Dexketoprofen is a non-steroidal anti-inflammatory drug (NSAID) used for the short-term relief of mild to moderate pain, such as muscle and joint pain, back pain, period pain, toothache and pain after minor surgery. The injection form is used in hospital for moderate to severe acute pain, for example after an operation.
How It Works
Dexketoprofen is the active half of the ketoprofen molecule. It blocks the cyclo-oxygenase (COX) enzymes that make prostaglandins, chemicals that cause pain, swelling and fever. Because only the active form is given, a smaller dose is needed and pain relief starts within about 30 minutes.
Dosage and Administration
- Tablets (adults): usually 25 mg every 8 hours, or 12.5 mg every 4 to 6 hours, as needed. Do not take more than 75 mg in 24 hours.
- Take with food if you have stomach discomfort; taking it on an empty stomach gives faster relief.
- Use the lowest dose for the shortest time, usually no more than 3 to 5 days. Older people and those with liver or kidney problems may need a lower dose.
- Injection: given by a doctor or nurse at the dose prescribed, usually for no more than 2 days.
Interactions
- Higher bleeding risk with Warfarin, Heparin, Clopidogrel, Aspirin, SSRIs (such as Sertraline) and corticosteroids.
- Do not combine with other NSAIDs such as Ibuprofen, Diclofenac or Naproxen.
- May reduce the effect of blood pressure medicines and diuretics and increase kidney risk with ACE inhibitors, angiotensin receptor blockers and diuretics.
- May raise levels of Lithium and Methotrexate.
Contraindications
- Active or past stomach ulcer or bleeding, or Crohn’s disease or ulcerative colitis.
- Asthma, hives or runny nose triggered by Aspirin or other NSAIDs.
- Severe heart failure, severe kidney or liver disease, bleeding disorders.
- Last 3 months of pregnancy, and breastfeeding.
- Children and adolescents under 18 years.
Side Effects
Common effects include nausea, vomiting, stomach pain, indigestion and diarrhoea. Less common: dizziness, drowsiness, headache, sleep problems, rash and fluid retention. Like other NSAIDs it can cause stomach ulcers or bleeding and may slightly increase the risk of heart attack or stroke.
Get urgent medical help if you vomit blood, have black stools, severe stomach pain, chest pain, sudden weakness or difficulty speaking, wheezing or difficulty breathing, swelling of the face or throat, or a blistering skin rash.
Pregnancy and Lactation
Do not use in the last 3 months of pregnancy, as it can harm the baby’s heart and kidneys and delay labour. In the first 6 months, use only if a doctor considers it essential. It is not recommended during breastfeeding.
Precautions and Warnings
- Take care if you have high blood pressure, heart disease, kidney or liver problems, asthma or are older.
- NSAIDs may reduce female fertility while being taken.
- May cause dizziness or drowsiness; do not drive if affected.
Overdose
Overdose may cause stomach pain, nausea, vomiting, drowsiness, dizziness and headache, and rarely stomach bleeding or kidney problems. Get medical help promptly.
Therapeutic Class
Non-steroidal anti-inflammatory drug (propionic acid derivative), analgesic.
Storage
Store below 30°C in a dry place, away from light. Keep injections as directed on the pack. Keep out of the reach of children.
Prepared by the Oshud Alo team from standard drug references. For information only; always follow your doctor's advice.