Indications
DHA (docosahexaenoic acid) is an omega-3 fatty acid found mainly in oily fish, fish oil and algae oil. It is a major building block of the brain and the retina of the eye. It is used as a supplement, often with EPA, to support heart, brain and eye health, during pregnancy and breastfeeding to support the baby’s brain and eye development, and in medical nutrition products for people who are ill or losing weight.
How It Works
DHA is built into the membranes of nerve and eye cells, helping them work properly. Like EPA, it is converted into substances that help resolve inflammation, and it helps lower blood triglycerides. During pregnancy and early infancy, the baby takes DHA from the mother to build the growing brain and eyes.
Dosage and Administration
Take as directed on the label or by a doctor or dietitian, usually with meals. In pregnancy and breastfeeding, about 200 to 300 mg of DHA a day is commonly advised. General supplements often provide 250 to 1,000 mg of combined EPA and DHA a day. Higher doses should be used only on medical advice.
Interactions
- Blood thinners and antiplatelet medicines (such as Warfarin, Aspirin, Clopidogrel): high doses may slightly increase the risk of bleeding.
- Blood pressure medicines: may add a small extra lowering effect.
- Orlistat may reduce absorption; take at different times.
Contraindications
- Allergy to fish or any ingredient (choose algae-based DHA if allergic to fish, after checking with a doctor).
- Active bleeding problems, unless a doctor advises.
Side Effects
Common effects include a fishy aftertaste, burping, indigestion, nausea and loose stools, which are reduced by taking it with food. High doses may increase the risk of bleeding.
Get urgent medical help if there is unusual bleeding or bruising, black stools, a racing or irregular heartbeat, or a rash with swelling of the face or difficulty breathing.
Pregnancy and Lactation
DHA is considered safe and beneficial in pregnancy and breastfeeding at usual doses. Choose purified products low in mercury, and avoid fish liver oils high in Vitamin A unless advised by a doctor.
Precautions and Warnings
- Tell your doctor before surgery if you take high doses.
- Check the oil source if you have a fish or shellfish allergy.
- Supplements do not replace a balanced diet or prescribed medicines.
Overdose
Very large amounts may cause diarrhoea, stomach upset and a higher risk of bleeding. Seek medical advice if bleeding occurs.
Therapeutic Class
Omega-3 fatty acid supplement.
Storage
Store below 30°C in a dry place, away from light and heat, with the container tightly closed. Keep out of the reach of children.
Prepared by the Oshud Alo team from standard drug references. For information only; always follow your doctor's advice.