Indications
Diacerein is used for long-term relief of the symptoms of osteoarthritis (wear-and-tear arthritis) of the hip and knee, such as pain and stiffness. It works slowly, so benefit usually appears only after 2 to 4 weeks of regular use.
How It Works
Diacerein is changed in the body to rhein, which reduces the action of interleukin-1, a substance that drives inflammation and cartilage breakdown in joints. This can ease pain and may slow cartilage damage.
Dosage and Administration
- Adults: usually 50 mg once a day with the evening meal for the first 2 to 4 weeks, then 50 mg twice a day with meals, or as the doctor advises.
- Swallow the capsule whole with a glass of water during a meal.
- Starting with the lower dose helps reduce diarrhoea. Stop and see the doctor if diarrhoea develops.
- Not recommended for people aged 65 years or older, or for children.
Interactions
Antacids containing aluminium, calcium or magnesium hydroxide can reduce absorption; take them at least 2 hours apart. Laxatives and some antibiotics can make diarrhoea worse. If diarrhoea occurs while taking diuretics such as Furosemide, or heart medicines such as Digoxin, potassium can fall and cause heart rhythm problems.
Contraindications
- Allergy to Diacerein, anthraquinones or any ingredient.
- Current or past liver disease.
- Inflammatory bowel disease (such as ulcerative colitis or Crohn’s disease), bowel obstruction, or unexplained stomach pain.
Side Effects
Diarrhoea and soft stools are very common, and stomach pain, wind and nausea can occur. Urine may turn dark yellow or brownish; this is harmless. Itching or rash may occur.
Get urgent medical help for: severe or persistent diarrhoea with weakness, dizziness or very little urine (signs of dehydration), yellowing of the skin or eyes, or a serious allergic reaction (swelling of the face or throat, difficulty breathing).
Pregnancy and Lactation
Not recommended in pregnancy. It should not be used while breastfeeding because small amounts pass into breast milk.
Precautions and Warnings
- Tell the doctor about any liver problems; liver symptoms should be watched for during treatment.
- Kidney disease may need a lower dose.
- Avoid alcohol in large amounts during treatment.
Overdose
Too much is likely to cause severe diarrhoea, which can lead to dehydration and loss of potassium. Drink fluids and seek medical help.
Therapeutic Class
Anti-osteoarthritis agent (slow-acting interleukin-1 inhibitor).
Storage
Store below 30°C in a dry place, away from light and out of the reach of children.
Prepared by the Oshud Alo team from standard drug references. For information only; always follow your doctor's advice.