Indications
Glutathione is the body’s main natural antioxidant, made inside cells from the amino acids cysteine, glutamic acid and glycine. As an oral supplement it is included in antioxidant formulas, including products intended to support male reproductive health, where oxidative damage to sperm is thought to contribute to poor sperm quality. It is also used for general antioxidant and liver support and is promoted for skin tone. Evidence for these uses when taken by mouth is limited.
How It Works
Glutathione protects cells by neutralising free radicals (unstable molecules that damage cell membranes and DNA), by recycling vitamins C and E, and by helping the liver detoxify certain substances. Sperm are especially sensitive to oxidative damage, so antioxidants may help protect their movement and DNA. Part of an oral dose is broken down during digestion, so the amount that reaches the blood may be small.
Dosage and Administration
Take by mouth as directed on the label of the product. Stand-alone supplements commonly provide 250 to 500 mg a day. For sperm health, antioxidant products are usually taken for at least 3 months. Injectable glutathione is not appropriate for self-use and should only be given by a health professional for a medical reason.
Interactions
No important interactions with oral glutathione are well established. High-dose antioxidants might reduce the effectiveness of some chemotherapy or radiotherapy, so people having cancer treatment should check with their specialist first.
Contraindications
- Allergy to glutathione or any other ingredient.
- During chemotherapy or radiotherapy, unless the specialist agrees.
Side Effects
Usually well tolerated. Some people have bloating, cramps, loose stools or a skin rash. Breathing problems have been reported mainly with inhaled forms in people with asthma.
Get urgent medical help for swelling of the face, lips or throat, wheezing or difficulty breathing, or a widespread rash.
Pregnancy and Lactation
There is not enough information on the safety of glutathione supplements in pregnancy or breastfeeding, so avoid them unless a doctor recommends them.
Precautions and Warnings
Male fertility problems should be assessed by a doctor, including a semen analysis, as some causes are treatable. Stopping smoking, limiting alcohol, keeping a healthy weight and avoiding overheating of the testicles also help sperm health. People with asthma should stop it if breathing symptoms occur.
Overdose
Taking more than directed is unlikely to be dangerous but may upset the stomach. Seek medical advice if you feel unwell and take the pack with you.
Therapeutic Class
Antioxidant food supplement
Storage
Store below 30°C in a dry place, away from light and out of the reach of children. Keep the container tightly closed.
Prepared by the Oshud Alo team from standard drug references. For information only; always follow your doctor's advice.