Indications
Levomefolate (L-methylfolate) is the active form of folate, also known as vitamin B9. It is used to prevent and treat folate deficiency, to support healthy folate levels before and during pregnancy to help prevent neural tube defects in the baby, and in people who convert Folic Acid poorly, such as those with certain MTHFR gene variants. Doctors may also use it to help lower high homocysteine levels and, in some cases, alongside antidepressant treatment.
How It Works
Folic Acid from ordinary supplements has to be converted by the body in several steps before it can be used. Levomefolate is already in the active form, so it can be used directly. Folate is needed to make DNA and new cells, including red blood cells, and for the normal development of the baby’s brain and spinal cord. It also helps convert homocysteine into other substances and supports the production of brain chemicals.
Dosage and Administration
Take as directed on the label or by your doctor, usually once a day with or without food. For general supplementation and pregnancy planning, products usually provide an amount similar to 400 mcg of Folic Acid a day. Higher doses are used only on medical advice.
Interactions
Folate may lower the blood levels of some antiepileptic medicines such as Phenytoin, Phenobarbital, Primidone and Carbamazepine, so seizure control should be watched. Medicines such as Methotrexate, Trimethoprim, Pyrimethamine and Sulfasalazine affect folate use in the body; tell your doctor if you take them. Some products combine Levomefolate with other vitamins; check the full label.
Contraindications
Do not use if you are allergic to any ingredient. Folate should not be used alone to treat anaemia caused by vitamin B12 deficiency (pernicious anaemia), because it may hide the anaemia while nerve damage continues.
Side Effects
Side effects are rare. They may include:
- Nausea, bloating or loss of appetite
- Sleep problems or irritability
- Skin rash or itching
Get urgent medical help if you develop swelling of the face, lips or throat, difficulty breathing or a widespread rash.
Pregnancy and Lactation
Folate is recommended before conception and in early pregnancy, and it is safe during breastfeeding at the usual supplement amounts. Follow your doctor’s advice on the dose, especially if you have had a previous pregnancy affected by a neural tube defect.
Precautions and Warnings
If you have anaemia, ask your doctor to check your vitamin B12 level before starting. People with epilepsy, cancer or those on folate-blocking medicines should use it only on medical advice. Do not take more than one folate-containing product at the same time unless advised.
Overdose
Folate has low toxicity, and excess is passed out in the urine. Very high amounts may cause stomach upset or sleep problems. Contact a doctor if a large amount has been taken.
Therapeutic Class
Vitamin (active folate, vitamin B9).
Storage
Store below 30°C in a dry place, away from light and out of the reach of children.
Prepared by the Oshud Alo team from standard drug references. For information only; always follow your doctor's advice.