Indications
Pepsin is a protein-digesting enzyme normally made by the stomach. In combination digestive enzyme products, often with Lipase, Pancreatin and cellulase, it is used to help relieve indigestion, a heavy or full feeling after meals, and bloating, particularly after protein-rich food such as meat, fish, eggs and pulses.
How It Works
The stomach lining releases pepsin in an inactive form that is switched on by stomach acid. Active pepsin cuts proteins into smaller pieces (peptides), which are then broken down further in the small intestine and absorbed. Extra pepsin taken with a meal adds to this first step of protein digestion. It works best in an acidic stomach.
Dosage and Administration
Take as directed on the label or by your doctor, usually with or just after meals. Powders are mixed with water or another drink as described on the pack.
Interactions
- Antacids and acid-reducing medicines such as Omeprazole, Esomeprazole or Ranitidine make the stomach less acidic and may reduce how well pepsin works.
- No other important interactions are known. Ask a pharmacist if you take other medicines regularly.
Contraindications
- Allergy to pepsin, pork or beef products (pepsin is usually taken from animal stomachs), or to any other ingredient.
- Active stomach or duodenal ulcer, unless a doctor advises otherwise.
Side Effects
Pepsin is usually well tolerated. Some people notice stomach discomfort, heartburn, nausea or loose stools. Allergic reactions are rare.
Get urgent medical help if you have a rash with swelling of the face, lips or throat, difficulty breathing, black or bloody stools, vomiting blood, or severe stomach pain.
Pregnancy and Lactation
There is little information on pepsin supplements in pregnancy or breastfeeding. Very little is expected to enter the body, but ask your doctor before use.
Precautions and Warnings
- See a doctor if indigestion keeps coming back, lasts more than two weeks, or comes with weight loss, trouble swallowing, vomiting or anaemia.
- Pepsin does not treat ulcers or acid reflux and may make heartburn worse in some people.
- Keep powders dry so the enzyme stays active.
Overdose
Taking too much is unlikely to be dangerous but may cause stomach upset or heartburn. Contact a doctor if symptoms are severe.
Therapeutic Class
Digestive enzyme (protein-digesting enzyme).
Storage
Store below 30°C in a dry place, away from light and out of the reach of children. Keep the container tightly closed.
Prepared by the Oshud Alo team from standard drug references. For information only; always follow your doctor's advice.