Indications
Piperine is the natural compound that gives black pepper (Piper nigrum) its sharp taste. It is used in dietary supplements, most often together with Curcumin (turmeric extract), mainly to help the body absorb Curcumin and some other nutrients better. Turmeric with Piperine supplements are commonly taken to support joint comfort and general wellbeing. Evidence for health benefits of Piperine on its own is limited.
How It Works
Piperine slows down certain enzymes in the gut wall and liver that normally break down substances before they reach the blood. This lets more Curcumin, and some other compounds, stay in the body for longer. It may also have mild anti-inflammatory and antioxidant effects.
Dosage and Administration
Take as directed on the label. In combined turmeric products Piperine is present in small amounts, usually a few milligrams per dose. Take with food and water. Do not take more than the recommended amount.
Interactions
Because Piperine can increase the blood levels of some medicines, take care with Phenytoin, Carbamazepine, Theophylline, Propranolol, Cyclosporine, Warfarin and other blood thinners, and medicines for diabetes. If you take any regular prescription medicine, ask a doctor or pharmacist before starting a Piperine-containing supplement.
Contraindications
- Known allergy to black pepper or Piperine.
- Active stomach ulcer or severe acid reflux.
- People taking medicines with a narrow safety margin (such as Phenytoin, Cyclosporine or Warfarin) should not use it without medical advice.
Side Effects
Usually well tolerated in supplement amounts. Possible effects include heartburn, stomach upset, a burning feeling in the throat, and nausea.
Get urgent medical help if you develop swelling of the face or throat, difficulty breathing, black or bloody stools, or a severe rash.
Pregnancy and Lactation
Black pepper in normal food amounts is safe, but the safety of concentrated Piperine supplements during pregnancy and breastfeeding has not been established. Avoid them unless a doctor advises otherwise.
Precautions and Warnings
- Stop taking Piperine supplements about two weeks before planned surgery, as it may affect bleeding and the handling of anaesthetic medicines.
- People with gallstones should ask a doctor before taking turmeric with Piperine.
- Not for children unless advised by a doctor.
Overdose
Large amounts may cause severe stomach irritation, vomiting and breathing discomfort. Seek medical help if much more than the recommended amount has been taken.
Therapeutic Class
Dietary supplement (bioavailability enhancer, plant extract)
Storage
Store below 30°C in a dry place, away from light and out of the reach of children.
Prepared by the Oshud Alo team from standard drug references. For information only; always follow your doctor's advice.