Citicoline
Indications
Citicoline is used as an add-on treatment to support recovery of the brain after a stroke or head injury, and for memory and thinking problems linked to reduced blood flow in the brain. In some countries it is also used for glaucoma. The evidence for these uses is mixed, and it does not replace standard stroke care.
How It Works
In the body it breaks down into choline and cytidine. These help build and repair the outer layers (membranes) of brain cells and make acetylcholine, a chemical messenger involved in memory.
Dosage and Administration
Tablets or oral solution, adults: usually 500 to 1000 mg a day in 1 or 2 doses, or as prescribed. It can be taken with or without food. Injection: given by a doctor or nurse into a vein or muscle, at a dose prescribed by the doctor.
Interactions
It may increase the effect of Levodopa. Do not use it together with Meclofenoxate. Tell your doctor about all the medicines you take.
Contraindications
Allergy to citicoline or any ingredient, and conditions with an overactive vagus nerve (vagotonia), which can cause a slow heartbeat and fainting.
Side Effects
Usually well tolerated. Possible effects include stomach upset, diarrhoea, headache, restlessness, trouble sleeping, dizziness, and changes in blood pressure.
Get urgent medical help for swelling of the face or difficulty breathing, or for new or worsening weakness, trouble speaking, a drooping face or a sudden severe headache, which can be signs of another stroke.
Pregnancy and Lactation
There is little safety information. Use during pregnancy or breastfeeding only if your doctor decides it is needed.
Precautions and Warnings
- After bleeding inside the skull, injections are given slowly and at a low dose under hospital care.
- It does not replace blood pressure, blood thinner or other treatments your doctor has prescribed after a stroke.
Overdose
Citicoline has low toxicity, and serious harm is unlikely. Seek medical advice if a large amount has been taken.
Therapeutic Class
Neuroprotective agent (nootropic).
Storage
Store below 30°C in a dry place, away from light and out of the reach of children. Do not freeze the oral solution or injection.
Prepared by the Oshud Alo team from standard drug references. For information only; always follow your doctor's advice.
All brands of Citicoline